Nurse practitioners in Missouri earn an average of $130,970 per year, with a median of $129,930. The close alignment between those two figures suggests the market is relatively stable, but the range from $100,650 at the 10th percentile to $162,060 at the 90th percentile means seniority and specialization still drive meaningful differences in what candidates will expect.
Nurse practitioner salary in Missouri (2026)
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The average nurse practitioner salary in Missouri is $130,970 per year. A small pool of very high earners pulls that average upward, so the median of $129,930 gives employers a more reliable starting point for most hiring decisions. Missouri employs 7,710 nurse practitioners, and the $1,040 gap between the mean and median signals real variation in the candidate pool you will be evaluating. Junior nurse practitioners in Missouri typically earn around $100,650, while senior specialists reach and exceed the $162,060 level at the 90th percentile. Plan for a range rather than a single number when budgeting for a nurse practitioner hire in Missouri, and anchor that range to the seniority and specialization of the role you are filling.
Metric / Value
Metric | Value |
Median Annual Salary | $129,930 |
Average Annual Salary | $130,970 |
vs. National Average | 4.6% below the national mean of $137,300 |
Data comes from the BLS OEWS and covers 7,710 employed nurse practitioners across Missouri.
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Nurse practitioner salary percentiles in Missouri
Percentile | Annual Salary |
10th Percentile | $100,650 |
25th Percentile | $119,910 |
75th Percentile | $144,640 |
90th Percentile | $162,060 |
Employers setting an offer for a nurse practitioner in Missouri should expect that most candidates will fall between $119,910 and $144,640, which covers the middle half of the market. Roles requiring specialized experience or leadership responsibilities will push compensation toward the $162,060 threshold that senior practitioners in Missouri typically reach or exceed.
Nurse practitioner salary by city in Missouri
City | Average Annual Salary |
St. Louis | $135,550 |
Kansas City | $130,010 |
Joplin | $128,980 |
Columbia | $124,080 |
Springfield | $123,890 |
Location meaningfully affects what you will need to budget for a nurse practitioner hire in Missouri. St. Louis commands the highest average at $135,550, which is $11,660 more than Springfield at $123,890, so employers hiring in the St. Louis market should set their range accordingly rather than defaulting to the statewide figure.
How Missouri compares to other states
State | Average Annual Salary | Median Annual Salary |
Missouri | $130,970 | $129,930 |
Illinois | $130,940 | $130,680 |
Kansas | $127,940 | $126,650 |
Indiana | $126,600 | $128,830 |
Ohio | $122,910 | $124,870 |
Tennessee | $115,510 | $117,590 |
Missouri sits at the top of this peer group, which means employers here face compensation expectations that are broadly in line with Illinois but higher than Kansas, Indiana, Ohio, and Tennessee. Missouri's mean of $130,970 is nearly identical to Illinois's $130,940, so cross-border recruiting between those two states carries little cost advantage either way. Employers considering candidates from Tennessee, where the mean is $115,510, should expect a meaningful adjustment in expectations when those candidates evaluate Missouri offers.
Frequently asked questions about nurse practitioner salary in Missouri
How much does a NP make in Missouri?
How does Missouri compare to other states for nurse practitioner salary?
Missouri ranks at the top of its regional peer group, with a mean of $130,970 that edges out Illinois at $130,940 and sits well above Tennessee at $115,510. For employers, this means Missouri is not a low-cost market relative to most neighboring states, and candidates relocating from Tennessee or Ohio will likely expect a pay increase. Budget accordingly when competing for talent across state lines.
What is the salary range for a nurse practitioner in Missouri?
The full documented range runs from $100,650 at the 10th percentile to $162,060 at the 90th percentile. The middle half of the market falls between $119,910 and $144,640, which is the most practical range to anchor your offer to for most roles. Positions requiring advanced specialization or significant clinical leadership will push toward or beyond the upper end of that band.
What is the average nurse practitioner salary in Missouri?
The average nurse practitioner salary in Missouri is $130,970 per year. That figure sits 4.6% below the national mean of $137,300, so employers recruiting nationally should be aware that candidates coming from higher-paying markets may expect an adjustment. Pairing your offer with the median of $129,930 gives you a grounded anchor that reflects what most practitioners in the state actually earn.
Nurse Practitioner salary by state
Data sourced from the U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), 2025, SOC code 29-1171 (Nurse Practitioners).
Disclaimer
Rippling and its affiliates do not provide tax, accounting, or legal advice. This material has been prepared for informational purposes only, and is not intended to provide or be relied on for tax, accounting, or legal advice. You should consult your own tax, accounting, and legal advisors before engaging in any related activities or transactions.
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The Rippling Team
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Jul 7, 2026
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Nurse practitioner salary in Missouri (2026)
Nurse practitioner salaries in Missouri average $130,970. See pay by percentile, city, and how Missouri compares to neighboring states.
Jul 7, 2026
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